Cannabidiolic acid (CBDA) is one of many compounds produced by cannabis and hemp. Abundant in the live plants of CBD varieties, it converts to the better known cannabinoid CBD (cannabidiol) over time and when exposed to heat. CBDA is typically found in capsules, tinctures, and topicals. Many people even juice raw cannabis to get a daily dose of CBDA.
Potential medical benefits of CBDA
While most cannabinoids bind directly with either the CB1 or CB2 receptors, CBDA doesn’t work in this way. Instead, CBDA interacts with the endocannabinoid system by inhibiting the cyclooxygenase-2 (COX-2) enzyme. COX-2 enzymes are associated with inflammation after an injury or infection, so by blocking COX-2 enzymes, CBDA can relieve inflammation and associated pain.